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  6. Ammonium glycyrrhizinate

Ammonium glycyrrhizinate  (Synonyms: 甘草酸铵盐; Monoammonium glycyrrhizinate; Glycyrrhizic acid ammonium salt; Ammonium glycyrrhizate)

目录号: HY-76225 纯度: 98.31%
COA 产品使用指南

摩尔计算器

Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) 具有抗炎、抗过敏、抗胃溃疡、抗肝炎等药理活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ammonium glycyrrhizinate Chemical Structure

Ammonium glycyrrhizinate Chemical Structure

CAS No. : 53956-04-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550
In-stock
50 mg ￥500
In-stock
100 mg ￥700
In-stock
500 mg ￥2100
In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Ammonium glycyrrhizinate:

Ammonium glycyrrhizinate 相关抗体

Top Publications Citing Use of Products

    Ammonium glycyrrhizinate purchased from MCE. Usage Cited in: Cell Prolif. 2020 Jun;53(6):e12829.  [Abstract]

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.

    体内研究
    (In Vivo)

    The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30 mg/kg) administration. Pretreatment with MAG (10 and 30 mg/kg) efficiently reduces the production of TNF-α and IL-1β. MAG (10, 30 mg/kg) significantly decreases NF-κB p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces IκB-α protein expression compared with the control group, whereas MAG (10 and 30 mg/kg) significantly increased I𝜅B-𝛼 expression, compared with the LPS group[1].
    Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    839.96

    Formula

    C42H65NO16
    CAS 号
    性状

    固体

    颜色

    White to off-white

    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 100 mg/mL (119.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.1905 mL 5.9527 mL 11.9053 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.98 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    • 方案 二

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.98 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

      20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料

    纯度: 98.31%

    COA (297 KB) HNMR (308 KB) LCMS (89 KB)

    产品使用指南 (1538 KB)
    参考文献
    Animal Administration
    [1][2]

    Mice[1]
    In this study, BALB/c mice (male, 6-8 weeks old, and 20-25 g) are used. Mice are randomly divided into five groups: control group, LPS group, and LPS + Monoammonium glycyrrhizinate (MAG: 3, 10, and 30 mg/kg) groups. Each group contains eight mice. Mice are anesthetized with intraperitoneal injection of sodium pentobarbital (50 mg/kg). Before inducing acute lung injury, the mice are given intraperitoneal injection with MAG (3, 10, and 30 mg/kg). One hour later, LPS (5 mg/kg) is instilled intratracheally to induce acute lung injury. Normal mice are given PBS[1].
    Rats[2]
    Male Wistar rats (180-220 g) are used. Rats are randomly divided into four groups, i.e., control group, RIF and INH group, MAG low-dose group, and MAG high-dose group, each group has 15 rats. Rats in the RIF and INH group receive RIF (60 mg/kg) and INH (60 mg/kg) by gavage administration once daily; rats in MAG groups are pretreated with MAG at the doses of 45 or 90 mg/kg, RIF (60 mg/kg) and INH (60 mg/kg) are given 3 h after MAG administration; rats in the control group are treated with saline. To evaluate the dynamic effect of drugs, rats in each group are sacrificed on 7, 14, and 21 d after drug administration[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Ammonium glycyrrhizinate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.1905 mL 5.9527 mL 11.9053 mL 29.7633 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL 5.9527 mL
    10 mM 0.1191 mL 0.5953 mL 1.1905 mL 2.9763 mL
    15 mM 0.0794 mL 0.3968 mL 0.7937 mL 1.9842 mL
    20 mM 0.0595 mL 0.2976 mL 0.5953 mL 1.4882 mL
    25 mM 0.0476 mL 0.2381 mL 0.4762 mL 1.1905 mL
    30 mM 0.0397 mL 0.1984 mL 0.3968 mL 0.9921 mL
    40 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7441 mL
    50 mM 0.0238 mL 0.1191 mL 0.2381 mL 0.5953 mL
    60 mM 0.0198 mL 0.0992 mL 0.1984 mL 0.4961 mL
    80 mM 0.0149 mL 0.0744 mL 0.1488 mL 0.3720 mL
    100 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2976 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ammonium glycyrrhizinate53956-04-0Monoammonium glycyrrhizinateGlycyrrhizic acid Ammonium glycyrrhizateOthersInhibitorinhibitorinhibit

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